Primary Identifier | MGI:104899 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 19070 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable kinase binding activity and protein-macromolecule adaptor activity. Predicted to be involved in negative regulation of hippo signaling. Is active in glutamatergic synapse and postsynapse. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human MOB4 (MOB family member 4, phocein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5. [provided by MGI curators] |