Primary Identifier | MGI:1924238 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 98711 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic forelimb morphogenesis; and respiratory system development. Located in membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human RDH10 (retinol dehydrogenase 10). PHENOTYPE: Embryos homozygous for null or hypomorphic alleles exhibit mid-gestational lethality, reduced Retinoic Acid signaling and abnormal limb, craniofacial, somite and cardiac morphology. [provided by MGI curators] |