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Protein Coding Gene : Tspyl2 TSPY-like 2

Primary Identifier  MGI:106244 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  52808
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA replication; negative regulation of cell growth; and regulation of protein kinase activity. Predicted to be located in chromatin and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TSPYL2 (TSPY like 2).
PHENOTYPE: Mice homozygous or hemizygous for a targeted allele are viable, fertile and do not exhibit increased tumor incidence; however, mutant mouse embryonic fibroblasts are impaired in cell cycle arrest following DNA damage induced by ionizing radiation. [provided by MGI curators]
  • synonyms:
  • DXHXS1008E,
  • RIKEN cDNA E130307F10 gene,
  • E130307F10Rik,
  • DENTT,
  • DXBwg1396e,
  • MGI:1926887,
  • MGI:1924263,
  • DNA segment, Chr X, 1008 expressed,
  • DNA segment, Chr X, Brigham & Women's Genetics 1396 expressed,
  • Tspyl2,
  • TSPY-like 2,
  • MGD-MRK-33936,
  • DNA segment, Chr X, human DXS1008E,
  • CINAP

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Canonical gene --> CDSs in specific strains.

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