Primary Identifier | MGI:106244 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 52808 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA replication; negative regulation of cell growth; and regulation of protein kinase activity. Predicted to be located in chromatin and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TSPYL2 (TSPY like 2). PHENOTYPE: Mice homozygous or hemizygous for a targeted allele are viable, fertile and do not exhibit increased tumor incidence; however, mutant mouse embryonic fibroblasts are impaired in cell cycle arrest following DNA damage induced by ionizing radiation. [provided by MGI curators] |