| Primary Identifier | MGI:7491692 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Pabpc1l |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/Cas9 technology generated a CG to TT change at position 410-411 (c.410_411delCGinsTT) resulting in a serine to phenylalanine substitution at amino acid 137 (S137F). In addition, a synonymous AAG to AAA p.K95 mutation and CAG to GAA p.E373 mutation were introduced to avoid gRNA recognition and excision. S137F is a variant identified in a family with female infertility. |
