Primary Identifier | MGI:1914049 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 66799 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in cellular response to misfolded protein; protein monoubiquitination; and proteolysis involved in protein catabolic process. Located in nucleus. Orthologous to human UBE2W (ubiquitin conjugating enzyme E2 W). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial prenatal, neonatal and early postnatal lethality, reduced male fertility and skin defects. [provided by MGI curators] |