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Protein Coding Gene : Sdhaf4 succinate dehydrogenase complex assembly factor 4
Primary Identifier  MGI:1915252 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  68002
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables enzyme activator activity. Involved in cellular respiration; mitochondrial respiratory chain complex II assembly; and positive regulation of succinate dehydrogenase activity. Acts upstream of or within innate immune response. Located in mitochondrion. Used to study dilated cardiomyopathy. Orthologous to human SDHAF4 (succinate dehydrogenase complex assembly factor 4).
PHENOTYPE: Mice with conditional loss of expression in the heart display premature lethality, dilated cardiomyopathy, and myocardial mitochondrial abnormalities. [provided by MGI curators]
  • synonyms:
  • 1110058L19Rik,
  • Sdhaf4,
  • expressed sequence AI847425,
  • RIKEN cDNA 1110058L19 gene,
  • RIKEN cDNA 1700001E18 gene,
  • AI847425,
  • MGI:2138344,
  • succinate dehydrogenase complex assembly factor 4,
  • MGI:1922711,
  • 1700001E18Rik
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For





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