| Primary Identifier | MGI:1277096 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 19243 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein tyrosine phosphatase activity. Involved in positive regulation of cell migration. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; nervous system; nose; retina; and skeleton. Orthologous to human PTP4A1 (protein tyrosine phosphatase 4A1). PHENOTYPE: A homozygous null mutation leads to an increase in preweaning lethality. Homozygous KO in combination with homozygous KO of Ptp4a2 is embryonic lethal. Heterozygous-homozygous and homozygous-heterozygous KO combinations lead to reduced male fertility, with the het-hom combination exacerbating the phenotype of single homozygous Ptp4a2 KO. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
