Primary Identifier | MGI:2429944 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 214854 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin protein ligase activity. Acts upstream of or within protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in early endosome. Is expressed in central nervous system; dorsal root ganglion; lung epithelium; metanephros; and renal vasculature. Orthologous to human NEURL3 (neuralized E3 ubiquitin protein ligase 3). PHENOTYPE: Mice homozygous for a null mutation display increased susceptibility to Riboviria infection. [provided by MGI curators] |