Primary Identifier | MGI:109252 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 20353 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in several processes, including nervous system development; regulation of postsynapse assembly; and semaphorin-plexin signaling pathway. Located in postsynaptic density and synaptic vesicle membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; enamel organ; ganglia; genitourinary system; and sensory organ. Orthologous to human SEMA4C (semaphorin 4C). PHENOTYPE: Mice homozygous for a targeted mutation exhibit exencephaly, neonatal lethality, and abnormal cerebellum morphology. [provided by MGI curators] |