| Primary Identifier | MGI:96546 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16178 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables interleukin-1 binding activity and interleukin-1 receptor activity. Acts upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm. Is expressed in several structures, including gut; pituitary gland; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in aggressive periodontitis; esophageal cancer; lung cancer; and organ system cancer. Orthologous to human IL1R2 (interleukin 1 receptor type 2). PHENOTYPE: Homozygous null mice show a prolonged inflammatory response in response to IL-1a. Mice show increased CD4+ T cell number and altered CD8 subtype ratio following sRBC immunization. Another null allele shows increased susceptibility to induced arthritis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
