| Primary Identifier | MGI:105383 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16182 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables interleukin-18 receptor activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including T-helper 1 cell differentiation; interleukin-18-mediated signaling pathway; and positive regulation of type II interferon production. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Is expressed in aorta-gonad-mesonephros and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1). PHENOTYPE: Mice homozygous for disruptions in this gene exhibit impaire Th1 cell development and defective NK cell physiology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
