| Primary Identifier | MGI:1338888 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16174 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable coreceptor activity and interleukin-18 receptor activity. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; neutrophil activation; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Is expressed in aorta-gonad-mesonephros. Orthologous to human IL18RAP (interleukin 18 receptor accessory protein). PHENOTYPE: Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
