| Primary Identifier | MGI:3611450 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 433294 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-lysine N-methyltransferase activity. Involved in protein methylation. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; hormone-mediated apoptotic signaling pathway; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Is expressed in alimentary system; diaphragm; genitourinary system; skeletal muscle; and skin. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine). PHENOTYPE: Mice homozygous for a knock-out allele exhibit muscle weakness, impaired exercise endurance, dysregulated autophagy during denervation-induced muscle atrophy, and reduced ATPase activity in skeletal muscle. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
