| Primary Identifier | MGI:95691 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 17700 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables heparin binding activity; protein homodimerization activity; and signaling receptor binding activity. Involved in several processes, including myoblast migration involved in skeletal muscle regeneration; negative regulation of skeletal muscle tissue growth; and positive regulation of lamellipodium assembly. Acts upstream of or within cellular response to dexamethasone stimulus and transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including abdominal wall; choroid plexus; connective tissue; embryo mesenchyme; and skeletal musculature. Used to study myostatin-related muscle hypertrophy. Human ortholog(s) of this gene implicated in myostatin-related muscle hypertrophy. Orthologous to human MSTN (myostatin). PHENOTYPE: Homozygotes for targeted and spontaneous mutations exhibit markedly increased size of striated muscle due to both hyperplasia and hypertrophy, reduced adiposity, and increased bone mineral density. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
