Primary Identifier | MGI:1328306 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 18393 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA replication origin binding activity. Predicted to be involved in DNA replication initiation. Located in heterochromatin. Part of inner kinetochore and nuclear origin of replication recognition complex. Is expressed in several structures, including 1st branchial arch maxillary component; brain; genitourinary system; sensory organ; and spleen. Orthologous to human ORC2 (origin recognition complex subunit 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation. [provided by MGI curators] |