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Protein Coding Gene : C2cd6 C2 calcium dependent domain containing 6
Primary Identifier  MGI:1920713 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  73463
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in flagellated sperm motility; sperm capacitation; and vesicle-mediated transport to the plasma membrane. Acts upstream of or within calcium ion transmembrane transport; protein-containing complex assembly; and single fertilization. Located in sperm principal piece. Part of CatSper complex. Is active in sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 68. Orthologous to human C2CD6 (C2 calcium dependent domain containing 6).
PHENOTYPE: Mice homozygous for a null allele exhibit male infertility associated with decreased hyperactivate sperm motility and reduced Cat Sper calcium channel capacity. [provided by MGI curators]
  • synonyms:
  • MGI:5898370,
  • amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (human),
  • C2 calcium dependent domain containing 6,
  • MGI:5898371,
  • Als2cr11b,
  • Als2cr11,
  • C2cd6,
  • amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11B,
  • 4930408G06Rik,
  • RIKEN cDNA 1700052H20 gene,
  • RIKEN cDNA 4930408G06 gene,
  • 1700052H20Rik,
  • C2cd6b,
  • MGI:5592748,
  • predicted gene, 33589,
  • MGI:1915429,
  • C2 calcium dependent domain containing 6B,
  • Gm33589
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