| Primary Identifier | MGI:106913 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 329165 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Involved in lens fiber cell morphogenesis; postsynaptic actin cytoskeleton organization; and regulation of dendritic spine morphogenesis. Acts upstream of or within camera-type eye development; generation of neurons; and learning or memory. Located in adherens junction and dendrite. Is active in dendritic spine; glutamatergic synapse; and postsynaptic actin cytoskeleton. Is expressed in several structures, including future brain; intestine smooth muscle circular layer; lens; nervous system; and trunk. Orthologous to human ABI2 (abl interactor 2). PHENOTYPE: Homozygous null mice display microphthalmia, abnormal lens development, abnormal corpus callosum, cerebral cortex, and hippocampus morphology, and impaired contextual conditioning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
