Primary Identifier | MGI:1935151 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 93691 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within axon guidance; dendrite morphogenesis; and positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; nervous system; and sensory organ. Orthologous to human KLF7 (KLF transcription factor 7). PHENOTYPE: Homozygous null mice die within 3 days of life, showing lack of gastic milk, hypopnea, cyanosis, olfactory bulb hypoplasia, no response to tail clamping, impaired axon projection in the olfactory and visual systems, cerebral cortex and hippocampus, and reduced dendritic branching in the hippocampus. [provided by MGI curators] |