| Primary Identifier | MGI:108571 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 14367 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Wnt-protein binding activity. Involved in camera-type eye development; canonical Wnt signaling pathway; and positive regulation of cytokine production. Acts upstream of or within several processes, including columnar/cuboidal epithelial cell maturation; embryonic organ development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; bicellular tight junction; and perinuclear region of cytoplasm. Colocalizes with early endosome. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; eye; and genitourinary system. Orthologous to human FZD5 (frizzled class receptor 5). PHENOTYPE: Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal. Mice homozygous for another null allele exhibit abnormal eye development with increased apoptosis and decreased retinal proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
