| Primary Identifier | MGI:87866 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 11363 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables long-chain fatty acyl-CoA dehydrogenase activity. Involved in several processes, including carnitine metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; and regulation of lipid metabolic process. Acts upstream of or within fatty acid catabolic process and response to cold. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Used to study very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADL (acyl-CoA dehydrogenase long chain). PHENOTYPE: Homozygous mutation of this gene results in reduced litter size, sudden death between 2-14 weeks of age, reduced serum glucose levels, lipid accumulation in the liver and heart, and cardiomyopathy. Heterozygous mutant animals exhibit reduced litter size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
