Primary Identifier | MGI:1913972 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 66722 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase binding activity. Involved in cilium assembly. Acts upstream of or within cerebrospinal fluid circulation; mucociliary clearance; and sperm axoneme assembly. Located in axonemal central apparatus and sperm flagellum. Orthologous to human SPAG16 (sperm associated antigen 16). PHENOTYPE: Chimeric males carrying one copy of the mutated allele have impaired spermatogenesis, a significant loss of germ cells at the round spermatid stage, and disorganized sperm axoneme structure. No offspring carrying the mutated allele are produced from matings using male chimeras. [provided by MGI curators] |