| Primary Identifier | MGI:96440 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16011 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables fibronectin binding activity and insulin-like growth factor binding activity. Involved in several processes, including lung alveolus development; negative regulation of skeletal muscle hypertrophy; and osteoblast differentiation. Acts upstream of or within several processes, including hair follicle morphogenesis; negative regulation of osteoblast differentiation; and regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of insulin-like growth factor ternary complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo ectoderm; heart and pericardium; limb; and metanephros. Orthologous to human IGFBP5 (insulin like growth factor binding protein 5). PHENOTYPE: Mice homozygous for one knock-out allele exhibit normal body weight and normal glucose homeostasis relative to wild-type controls. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
