| Primary Identifier | MGI:108071 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 22409 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within neural crest cell differentiation; positive regulation of gene expression; and regulation of odontogenesis of dentin-containing tooth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Schopf-Schulz-Passarge syndrome; ectodermal dysplasia; and tooth agenesis. Orthologous to human WNT10A (Wnt family member 10A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit taurodontism, supernumerary molars, small molars and misshapened crowns. Mice homozygous for a conditional allele activated in Krt14+ cells also exhibit decreased basal cell proliferation affecting the tongue, sweat glands and nails. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
