Primary Identifier | MGI:3619376 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 723900 |
Mgi Type | miRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within type B pancreatic cell development. Is expressed in Meckel's cartilage; pancreas; and skeleton. Orthologous to human MIR375 (microRNA 375). PHENOTYPE: Mice homozygous for a null mutation display hyperglycemia, hyperglucagonemia, decreased beta cell numnber and mass, increased alpha cell number, increased insulin and glucagon secretion, and enhanced gluconeogenesis. [provided by MGI curators] |