| Primary Identifier | MGI:2444274 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 241116 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in sperm axoneme assembly. Located in cytoplasm and sperm flagellum. Is expressed in lateral ventricle choroid plexus; lung; metencephalon part of 4th ventricle choroid plexus; and testis. Used to study spermatogenic failure 40. Human ortholog(s) of this gene implicated in spermatogenic failure 40. Orthologous to human CFAP65 (cilia and flagella associated protein 65). PHENOTYPE: Mice homozygous for a frameshift mutation display male sterility with multiple sperm flagella malformations and asthenospermia. Males homozygous for a knock-out allele are sterile and show severe oligoasthenoteratospermia with defects in sperm head shaping, acrosome formation and flagellar assembly. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
