| Primary Identifier | MGI:1916068 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 68818 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables K48-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein targeting to ER; and regulation of insulin-like growth factor receptor signaling pathway. Located in endoplasmic reticulum and membrane. Part of proteasome complex. Orthologous to human ZFAND2B (zinc finger AN1-type containing 2B). PHENOTYPE: Mice homozygous for a knock-out allele die prematurely due to a myeloproliferative disorder characterized by splenomegaly, increased WBC and platelet count, increased hematocrit, reduced long-term hematopoietic stem cells (HSCs) in bone marrow and spleen, and increased LSK+ and progenitor cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
