| Primary Identifier | MGI:96569 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 16322 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity and inhibin binding activity. Predicted to be involved in several processes, including gonad development; hemoglobin biosynthetic process; and negative regulation of follicle-stimulating hormone secretion. Predicted to be located in neuronal cell body; photoreceptor inner segment; and photoreceptor outer segment. Predicted to be part of inhibin A complex; inhibin B complex; and inhibin-betaglycan-ActRII complex. Predicted to be active in extracellular space. Is expressed in several structures, including enteric nervous system; forelimb bud; gut; heart; and reproductive system. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human INHA (inhibin subunit alpha). PHENOTYPE: Mutant mice develop gonadal sex cord-stromal tumors with nearly 100% penetrance and develop cachexia-like symptoms. The wasting syndrome is not observed in gonadectomized mutant mice, which develop adrenal tumors. Homozygous inhibition of inhibin activity leads to increased ovulation but reduced embryo/fetal/newborn survival of offspring of affected mothers, while heterozygote mothers show increased fecundity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
