| Primary Identifier | MGI:98277 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 13838 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GPI-linked ephrin receptor activity; identical protein binding activity; and transmembrane-ephrin receptor activity. Involved in several processes, including axon development; positive regulation of protein kinase activity; and regulation of neuron projection development. Acts upstream of or within several processes, including adult walking behavior; nephric duct morphogenesis; and nervous system development. Located in several cellular components, including axon; dendrite; and early endosome membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human EPHA4 (EPH receptor A4). PHENOTYPE: Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections resulting in a hopping gait. Heterozygotes show a less severe phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
