| Primary Identifier | MGI:101780 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 20720 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in negative regulation of plasminogen activation and negative regulation of platelet aggregation. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Located in extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). PHENOTYPE: Mice homozygous for a targeted mutation of this gene are viable and healthy but develop epileptic activity as well as reduced theta burst-induced LTP and NMDA receptor-mediated synaptic transmission in the CA1 field of the hippocampus; notably, homozygous mutant males are infertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
