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Protein Coding Gene : Agfg1 ArfGAP with FG repeats 1
Primary Identifier  MGI:1333754 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  15463
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable DNA binding activity; GTPase activator activity; and metal ion binding activity. Acts upstream of or within acrosome assembly; intermediate filament organization; and spermatid nucleus differentiation. Located in cell projection; cytoplasmic vesicle; and neuronal cell body. Used to study oligoasthenoteratozoospermia. Orthologous to human AGFG1 (ArfGAP with FG repeats 1).
PHENOTYPE: Male mice homozygous for disruptions in this gene are infertile as a result of abnormalities in spermatogenesis. Otherwise, males and females are normal and live a normal life span. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA C130049H11 gene,
  • Hrb,
  • MGI:1925111,
  • C130049H11Rik,
  • D730048C23Rik,
  • Rip,
  • C85612,
  • HIV-1 Rev binding protein,
  • Agfg1,
  • expressed sequence C85612,
  • ArfGAP with FG repeats 1,
  • MGI:2138506,
  • RIKEN cDNA D730048C23 gene,
  • AU045498,
  • MGI:2138706,
  • MGI:2444445,
  • expressed sequence AU045498
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2 Involved In Mutations

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Proteins

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Homology

Genes --> Homologs

Interactions

3 Pathways

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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