Primary Identifier | MGI:2152889 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 227325 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Notch binding activity. Acts upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Located in dendrite and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; limb; peripheral nervous system ganglion; and sensory organ. Orthologous to human DNER (delta/notch like EGF repeat containing). PHENOTYPE: Homozygous null mice display delayed cerebellar development, abnormal Bergmann glial cells, abnormal Purkinje cell innervation, and impaired coordination. [provided by MGI curators] |