| Primary Identifier | MGI:109323 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 15559 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G protein-coupled serotonin receptor activity; GTPase activator activity; and serotonin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; phospholipase C-activating serotonin receptor signaling pathway; and positive regulation of endothelial cell proliferation. Acts upstream of or within heart development. Located in cytoplasm and plasma membrane. Part of G protein-coupled serotonin receptor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). PHENOTYPE: Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
