| Primary Identifier | MGI:97369 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18159 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables signaling receptor binding activity. Involved in several processes, including c-di-GMP signaling; growth plate cartilage development; and oogenesis. Acts upstream of or within several processes, including negative regulation of meiotic cell cycle; negative regulation of oocyte maturation; and regulation of growth. Predicted to be located in extracellular space and secretory granule. Predicted to be part of protein-containing complex. Is expressed in central nervous system and vertebral cartilage condensation. Used to study achondroplasia and osteochondrodysplasia. Human ortholog(s) of this gene implicated in depressive disorder and hypertension. Orthologous to human NPPC (natriuretic peptide C). PHENOTYPE: Homozygotes for a targeted null mutation exhibit severe dwarfism due to impaired endochondral ossification. Mutants are viable at birth, but fewer than half survive postnatal development. Mice homozygous for a knock-out allele exhibit abnormal secondarysensory axon bifurcation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
