| Primary Identifier | MGI:2442555 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 208718 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 3'-5'-RNA exonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Involved in miRNA catabolic process and stem cell population maintenance. Located in cytoplasm. Is expressed in several structures, including central nervous system; ganglia; metanephros; molar; and nose. Used to study Perlman syndrome. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). PHENOTYPE: Null mice are perinatal lethal, exhibit respiratory failure upon caesarean delivery, and exhibit bradykinesia, abnormal spine curvature, and genitourinary abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
