Primary Identifier | MGI:1914440 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 26987 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA cap binding activity; translation initiation factor activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in P-body. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including brain; early conceptus; intestine; lung; and oocyte. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). PHENOTYPE: Mice homozygous for a null mutation display complete neonatal lethality, cyanosis, decreased birth weight and decreased brain size. [provided by MGI curators] |