| Primary Identifier | MGI:1195265 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18627 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including enzyme binding activity; nucleic acid binding activity; and transcription corepressor binding activity. Involved in several processes, including carbohydrate biosynthetic process; monocarboxylic acid metabolic process; and regulation of macromolecule metabolic process. Acts upstream of or within circadian rhythm and negative regulation of transcription by RNA polymerase II. Located in nucleus and perinuclear region of cytoplasm. Part of Cry-Per complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study advanced sleep phase syndrome 1. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome; advanced sleep phase syndrome 1; alcohol dependence; cocaine dependence; and fetal alcohol spectrum disorder. Orthologous to human PER2 (period circadian regulator 2). PHENOTYPE: Homozygous null mutants have a partially functional circadian clock, exhibiting a short circadian period followed by loss of circadian rhythmicity in constant darkness. Mutants are also deficient in DNA damage responses and show increased sensitivity togamma radiation and tumor development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
