| Primary Identifier | MGI:1858494 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 51800 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of mitochondrial depolarization; negative regulation of programmed cell death; and positive regulation of response to endoplasmic reticulum stress. Acts upstream of or within neuron apoptotic process. Located in several cellular components, including bounding membrane of organelle; mitochondrial membrane; and trans-Golgi network membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; retina; and vibrissa dermal component. Orthologous to human BOK (BCL2 family apoptosis regulator BOK). PHENOTYPE: Mice homozygous for a knock-out allele exhibit minor increase in spleen and thymus weight in female, but not male, mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
