| Primary Identifier | MGI:1314891 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 21934 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables tumor necrosis factor receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including lymph node development; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Located in cell surface and membrane raft. Is expressed in bladder; hemolymphoid system; hindlimb long bone; and mandible. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in bone development disease and bone remodeling disease (multiple). Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a). PHENOTYPE: Mice homozygous for a knock-out or spontaneous allele exhibit a failure of tooth eruption, osteopetrosis, and abnormal immune system morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
