| Primary Identifier | MGI:1100499 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 20479 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP hydrolysis activity and protein homodimerization activity. Involved in late endosomal microautophagy; multivesicular body assembly; and viral budding from plasma membrane. Acts upstream of or within several processes, including canonical Wnt signaling pathway; establishment of blood-brain barrier; and potassium ion transport. Located in cytosol. Is expressed in central nervous system; head; and migrating neural crest. Orthologous to human VPS4B (vacuolar protein sorting 4 homolog B). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality at approximately E9.5 and show placental abnormalities. Mouse embryonic fibroblasts from mice heterozygous for Vps4a and Vps4b null alleles exhibit increased endo/lysosomal organelles with large multi-membrane structures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
