| Primary Identifier | MGI:1309998 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 17167 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable amyloid-beta binding activity and cargo receptor activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Acts upstream of or within apoptotic cell clearance. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in spleen. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). PHENOTYPE: Mice homozygous for a null allele show altered spleen marginal zone architecture and impaired IgM responses to a pneumococcal polysaccharide vaccine. Mice homozygous for another null allele show increased susceptibility to bacterial pneumonia and enhanced inflammatory responses to inhaled particles. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
