| Primary Identifier | MGI:1914192 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 66942 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human DDX18 (DEAD-box helicase 18). PHENOTYPE: Homozygous null mice exhibit embryonic growth arrest and complete lethality before implantation. Mice homozygous for a null allele arrest at the morula stage, fail to form blastoceles, and show loss of pluripotency in early development. Mice homozygous for a different null allele show failure of morula compaction. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
