| Primary Identifier | MGI:2442596 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 226418 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein deubiquitination. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human YOD1 (YOD1 deubiquitinase). PHENOTYPE: Mice homozygous for a knock-out allele show increased susceptibility to methicillin-resistant Staphylococcus aureus (MRSA) infection with increased MRSA-induced septic death and NLRP3 inflammasome-mediated coagulation activation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
