| Primary Identifier | MGI:1916419 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 69169 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables IgM binding activity. Involved in humoral immune response mediated by circulating immunoglobulin; immunoglobulin transcytosis in epithelial cells; and regulation of B cell receptor signaling pathway. Acts upstream of or within negative regulation of cysteine-type endopeptidase activity; negative regulation of extrinsic apoptotic signaling pathway; and negative regulation of lymphocyte apoptotic process. Located in external side of plasma membrane and trans-Golgi network membrane. Orthologous to human FCMR (Fc mu receptor). PHENOTYPE: Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
