| Primary Identifier | MGI:1926375 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 54354 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of lymphocyte proliferation; positive regulation of protein ubiquitination; and regulation of protein localization to nucleus. Located in nucleus. Is expressed in heart and thymus primordium. Used to study systemic lupus erythematosus. Orthologous to human RASSF5 (Ras association domain family member 5). PHENOTYPE: Homozygotes for a null allele have defects in lymphocyte homing to lymphoid tissues, B cell maturation and dendritic cell function, and display lymphocyte hyperproliferation leading to lupus glomerulonephritis and lymphomas. Homozygotes for another null allele are resistant to TNF-induced apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
