| Primary Identifier | MGI:107934 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 17248 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable enzyme binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Acts upstream of or within heart development; positive regulation of cell population proliferation; and regulation of heart rate. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Is expressed in several structures, including eye; genitourinary system; liver; lung; and spleen. Used to study dilated cardiomyopathy. Orthologous to human MDM4 (MDM4 regulator of p53). PHENOTYPE: Mice homozygous for a gene trap allele exhibit embryonic lethality, decreased cellular proliferation, and abnormal nervous system development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
