Primary Identifier | MGI:2151113 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 269120 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in collagen fibril organization. Acts upstream of or within negative regulation of angiogenesis. Located in extracellular matrix. Is expressed in ciliary body; ciliary epithelium; cortical plate; and retina. Orthologous to human OPTC (opticin). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased preretinal neovascularization in an oxygen-induced retinopathy model. [provided by MGI curators] |