Primary Identifier | MGI:1351485 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 27280 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatidylinositol phosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system; intestine; and liver. Orthologous to human PHLDA3 (pleckstrin homology like domain family A member 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal embryonic and placental weight. [provided by MGI curators] |