| Primary Identifier | MGI:1921579 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 67313 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in adherens junction maintenance; intestinal epithelial structure maintenance; and positive regulation of protein ubiquitination. Predicted to be located in cytoplasm and nuclear body. Is expressed in gut; metanephros; olfactory epithelium; respiratory system; and submandibular gland primordium. Human ortholog(s) of this gene implicated in inflammatory bowel disease 29. Orthologous to human INAVA (innate immunity activator). PHENOTYPE: Mice homozygous for a knock-out allele have defects in the intestinal epithelial cell barrier and exhibit increased susceptibility to DSS-induced colitis and Citrobacter rodentium infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
