Primary Identifier | MGI:1316721 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 16876 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell population proliferation and gonad development. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; heart and pericardium; limb; nervous system; and sensory organ. Orthologous to human LHX9 (LIM homeobox 9). PHENOTYPE: Homozygotes for a targeted null mutation exhibit failed proliferation of the somatic cells of the genital ridge resulting in lack of discrete gonad formation, infertility in both sexes, and female-like genitalia in genetically male mice. [provided by MGI curators] |